(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester → HCID 178525640, compound

HRID 731483Notes

Reaction equation

HRID 731483 reaction equation
C1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24](COC3C=CC=CC=3)[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16]C(O)=O)=[CH:13][N:14]=2)CCCCC1.C1(N[C@H:42]2[CH2:47][CH2:46][C@H:45]([CH2:48][O:49][C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[CH2:44][CH2:43]2)CCCCC1.C([O:58][C:59](=[O:69])[CH:60](SC1SC(N)=NC=1)C)C>>[CH:21]1([N:7]([C@H:42]2[CH2:43][CH2:44][C@H:45]([CH2:48][O:49][C:50]3[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=3)[CH2:46][CH2:47]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][CH2:60][C:59]([OH:69])=[O:58])=[CH:13][N:14]=2)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 178420520HCID 178420520, compoundHCID 178526035HCID 178526035, compound

Product 1

HCID 178525640HCID 178525640, compound

Procedure

Prepared in an similar manner to {2-[3-cyclohexyl-3-(trans-4-phenoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-(trans-4-phenoxymethyl-cyclohexyl)-amine and (2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-0e0f7868b05048188dff56287e2d80a9
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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