(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester → HCID 178492589, compound

HRID 731484Notes

Reaction equation

HRID 731484 reaction equation
[CH:1]1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24](COC3C=CC=CC=3)[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15]CC(O)=O)=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(N[C@H]2CC[C@H]([CH2:48][O:49][C:50]3[CH:55]=[CH:54][C:53]([O:56][CH3:57])=[CH:52][CH:51]=3)CC2)CCCCC1.C([O:60][C:61](=[O:71])[CH:62](SC1SC(N)=NC=1)[CH3:63])C>>[CH:1]1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24]([CH2:57][O:56][C:53]3[CH:52]=[CH:51][C:50]([O:49][CH3:48])=[CH:55][CH:54]=3)[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:63][CH2:62][C:61]([OH:71])=[O:60])=[CH:13][N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 178492587HCID 178492587, compoundHCID 178526035HCID 178526035, compound

Product 1

HCID 178492589HCID 178492589, compound

Procedure

Prepared in an similar manner to {2-[3-cyclohexyl-3-(trans-4-phenoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-[trans-4-(4-methoxy-phenoxymethyl)-cyclohexyl]-amine and (2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-91ea2e5bcfc44a36b0d6566102cb3744
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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