(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester → HCID 178525641, compound

HRID 731485Notes

Reaction equation

HRID 731485 reaction equation
C1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24](COC3C=CC=CC=3)[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16]C(O)=O)=[CH:13][N:14]=2)CCCCC1.C1(N[C@H:42]2[CH2:47][CH2:46][C@H:45]([CH2:48][O:49][C:50]3[CH:55]=[CH:54][C:53]([F:56])=[CH:52][CH:51]=3)[CH2:44][CH2:43]2)CCCCC1.C([O:59][C:60](=[O:70])[CH:61](SC1SC(N)=NC=1)C)C>>[CH:21]1([N:7]([C@H:42]2[CH2:43][CH2:44][C@H:45]([CH2:48][O:49][C:50]3[CH:51]=[CH:52][C:53]([F:56])=[CH:54][CH:55]=3)[CH2:46][CH2:47]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][CH2:61][C:60]([OH:70])=[O:59])=[CH:13][N:14]=2)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 178505897HCID 178505897, compoundHCID 178526035HCID 178526035, compound

Product 1

HCID 178525641HCID 178525641, compound

Procedure

Prepared in a similar manner to {2-[3-cyclohexyl-3-(trans-4-phenoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-[trans-4-(4-fluoro-phenoxymethyl)-cyclohexyl]-amine and (2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-46fac0fd46854ddeb21bc2ca6750601e
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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