Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate → HCID 178495634, compound

HRID 731486Notes

Reaction equation

HRID 731486 reaction equation
[CH:1]1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24]([CH2:27][O:28][CH3:29])[CH2:23][CH2:22]2)[C:8](=[O:20])NC2SC(SCC(O)=O)=CN=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(N[C@H]2CCC[C@H](COC)CC2)CCCCC1.C([O:49][C:50](=[O:61])[C:51]([S:54][C:55]1[S:59][C:58]([NH2:60])=[N:57][CH:56]=1)([CH3:53])[CH3:52])C>>[CH:1]1([N:7]([C@H:21]2[CH2:22][CH2:23][C@H:24]([CH2:27][O:28][CH3:29])[CH2:25][CH2:26]2)[C:8](=[O:20])[NH:60][C:58]2[S:59][C:55]([S:54][C:51]([CH3:52])([CH3:53])[C:50]([OH:49])=[O:61])=[CH:56][N:57]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 67483663Cyclohexyl-(trans-4-methoxymethyl-cycloheptyl)amineHCID 178495639HCID 178495639, compound

Product 1

HCID 178495634HCID 178495634, compound

Procedure

Prepared in an similar manner to {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-(trans-4-methoxymethyl-cycloheptyl)-amine and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-41f268436c974478adced46280296643
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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