Cyclohexanone → HCID 178420523, compound

Participants

Reaction Steps

To a mixture of trans-4-phenoxycyclohexylamine (1 mmol) in 6 ml of THF and 6 ml of MeOH was added cyclohexanone (2 mmol), NaOAc (2 mmol) and 3 g of 3 Å molecular sieves. The mixture is stirred for 10 min after which 1N sodiumcyanoborohydride in tetrahydrofuran (2.4 mmol) is added. The reaction is stirred 1 day at room temperature then filtered through celite washing through with 30 mL of dichloromethane. The organic phase is washed with 10 ml of water, 10 mL of brine, dried (MgSO4), filtered and concentrated in vacuo to give crude cyclohexyl-(trans-4-phenoxy-cyclohexyl)amine which was used in the next step without further purification.

Provenance & Evidence