Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoate → HCID 178525642, compound

HRID 731491Notes

Reaction equation

HRID 731491 reaction equation
[CH:1]1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24](OC3C=CC=CC=3)[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16]C(O)=O)=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(N[C@H]2CC[C@H]([O:47][C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][N:49]=3)CC2)CCCCC1.C([O:56][C:57](=[O:67])[CH2:58]CSC1SC(N)=NC=1)C>>[CH:1]1([N:7]([C@H:21]2[CH2:22][CH2:23][C@H:24]([O:47][C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][N:49]=3)[CH2:25][CH2:26]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][CH2:58][C:57]([OH:67])=[O:56])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 57481428Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoateHCID 178420524HCID 178420524, compoundHCID 178526036HCID 178526036, compound

Product 1

HCID 178525642HCID 178525642, compound

Procedure

Prepared in a similar manner {2-[3-cyclohexyl-3-(trans-4-phenoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-[trans-4-(pyridin-2-yloxy)-cyclohexyl]-amine and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-19359a5c485a4f2c93ff0d481da47069
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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