HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 6-Amino-2-{[(2,3-difluorophenyl)methyl]sulfanyl}pyrimidin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(Bromomethyl)-2,3-difluoro-benzene | HCID 517984 | — |
| Reactant | HCID 178507962 | HCID 178507962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Amino-2-{[(2,3-difluorophenyl)methyl]sulfanyl}pyrimidin-4(1H)-one | HCID 135966721 | 81% |
Reaction Steps
4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate (7.1 g) was added portion wise to a stirred suspension of 60% sodium hydride (2.4 g) in dry N,N-dimethylformamide (70 ml). After 1 hour a solution of 2,3-Difluorobenzyl bromide (10 g) in dry N,N-dimethylformamide (10 ml) was added. Stirred over weekend at room temperature. Poured on to ice/water and the precipitate was collected by filtration to give 9.6 g of product. 81% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585867B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-a939c13c6f27424abbbd485911d8cefe |
| Source note | uspto-grants-2009_09 |