Methyl iodide → HCID 16109134, compound

Participants

Reaction Steps

A solution of EXAMPLE 1C (17.89 g, 50.1 mmol) in THF (150 mL) and HMPA (33 mL) was treated with NaH (4.0 g of a 60% dispersion, 100 mmol) at 0° C., stirred for 30 minutes, treated with CH3I (20 mL, 321 mmol), and stirred overnight. The reaction mixture was partitioned between ethyl acetate and saturated aqueous NH4Cl. The organic layer was washed with water (2×), dried (MgSO4), and filtered. Filtration of the concentrate provided the desired product which was used without further purification. MS (ESI) m/e 372 (M+H)+.

Provenance & Evidence