HCID 59803608, compound → (3R)-3-Amino-N,N-dimethyl-4-(phenylsulfanyl)butanamide

Participants

Reaction Steps

A suspension of EXAMPLE 1K (10.60 g, 28.46 mmol) in 50 mL 30% HBr/acetic acid was stirred at room temperature overnight. The resulting homogeneous reaction mixture was concentrated, diluted with water (200 mL) and 5% HCl (100 mL), and washed with diethyl ether (3×). The aqueous phase was adjusted to pH ˜8-9 with solid Na2CO3 and extracted with dichloromethane (5×). The combined organic phases were dried (MgSO4), filtered, and concentrated to give the desired product (6.54 g, 96%). MS (CI) m/e 239 (M+H)+.

Provenance & Evidence