Water → HCID 59186632, compound

Participants

Reaction Steps

A solution of EXAMPLE 15B (0.51 g, 1.80 mmol) in acetone (10 mL) was treated with water (5 mL) and p-toluenesulfonic acid monohydrate (0.20 g), heated to reflux, stirred overnight, and concentrated to remove the acetone. The remaining aqueous solution was extracted with ethyl acetate (3×100 mL) and the combined extracts were washed sequentially with 1N NaOH, water, and brine, dried (Na2SO4), filtered, and concentrated to provide the desired product (0.42 g, 100%). MS (ESI) m/e 233 (M+H)+.

Provenance & Evidence