Acetic Acid → HCID 59186703, compound

Participants

Reaction Steps

A solution of EXAMPLE 15C (0.42 g, 1.80 mmol) and 1-tert-butoxycarbonylpiperazine (0.391 g, 2.10 mmol) in dichloroethane (10 mL) at room temperature was treated with acetic acid (500 μL) and sodium triacetoxyborohydride (10.89 g, 4.2 mmol), stirred overnight, diluted with ethyl acetate (300 mL), washed sequentially with 1N NaOH, water, and brine, dried (Na2SO4), filtered, and concentrated to provide the desired product (0.51 g, 70%); MS (ESI) m/e 403 (M+H)+.

Provenance & Evidence