反应详情

A solution of EXAMPLE 21B (13.5 g, 57.4 mmol) and morpholine (10.0 mL, 115 mmol) in dioxane (100 mL) was stirred at 70° C. for 18 hours. The solution was concentrated and purified by silica gel chromatography eluting with 10% methanol/ethyl acetate to provide the desired product 6.0 g, 86%).

1. concentrationThe solution was concentrated
2. custompurified by silica gel chromatography
3. washeluting with 10% methanol/ethyl acetate