Water → HCID 22028180, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-[(4-fluorophenyl)thio]-1H-pyrrolo[2,3-b]pyridine (3.36 g, 13.8 mmol) in acetone is treated with a solution of NaHCO3 (2.90 g, 34.5 mmol) in water. The reaction is then treated with Oxone®1 (25.5 g, 41.4 mmol), stirred for 3 h at 20° C., diluted with water, cooled in an ice-water bath and filtered. The filtercake is washed with water and vacuum dried to afford the title compound as a white solid 1.73 g, mp 212-213° C., characterized by mass spectral and NMR analyses. 12KHSO5.KHSO4.K2SO4, manufactured by DuPont, Wilmington, Del.

Provenance & Evidence