HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium ethoxide → 4-Azaindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide | HCID 12146853 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Azaindole | HCID 9226 | — |
Reaction Steps
A mixture of 2,2,2-trifluoro-N-(2-trimethylsilan-ylethynylpyridin-3-yl)acetamide (1.0 eq) and sodium ethoxide (5 eq.) in ethanol is heated at reflux temperature for 10 h, cooled and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to give the title 4-azaindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585876B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-15f7cf4f5e854ea4940f8df56fe1e545 |
| Source note | uspto-grants-2009_09 |