HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 731590Generated: October 30, 2026
HCID 12146854, compound → 2-(1H-Pyrrolo[3,2-b]pyridin-3-yl)ethanamine
https://huagongshe.com/reaction/731590
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 12146854 | HCID 12146854 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-(1H-Pyrrolo[3,2-b]pyridin-3-yl)ethanamine | HCID 12146849 | — |
Reaction Steps
A solution of 2-oxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)acetamide (1 eq.) in ether is treated with lithium aluminum hydride (4 eq.), heated at reflux temperature for 8 h, cooled to 0° C., quenched by addition of Rochelle's salt solution and extracted with CH2Cl2. The extracts are combined, dried over MgSO4 and concentrated to afford the title amine, which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07585876B2 |
|---|
| Source dataset | uspto-grants-2009_09 |
|---|
| ORD ID | ord-b28922833a2d49e7a273e586d7e6d236 |
|---|
| Source note | uspto-grants-2009_09 |
|---|
