HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-(1H-Pyrrolo[3,2-c]pyridin-3-yl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Dimethyl-(1H-pyrrolo[3,2-c]pyridin-3-ylmethyl)-amine | HCID 19013583 | — |
| Product | 2-(1H-Pyrrolo[3,2-c]pyridin-3-yl)acetonitrile | HCID 22663052 | 26% |
Reaction Steps
Using essentially the same procedure described in Example 1, Step 5, hereinabove and employing N,N-dimethyl-(1H-pyrrolo[3,2-c]pyridin-3-yl)methylamine as substrate and 1:2 ethanol:ethyl acetate as the chromatography eluent affords the title acetonitrile as a yellow solid, 0.160 g (26% yield), identified by NMR analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585876B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-bc853f5cc58742eb8f86b13830ba92b3 |
| Source note | uspto-grants-2009_09 |