2-(1H-Pyrrolo[3,2-c]pyridin-3-yl)acetonitrile → 2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethanamine

Participants

Reaction Steps

A mixture of (1H-pyrrolo[3,2-c]pyridin-3-yl)-acetonitrile (0.260 g, 1.66 mmol) and 5% rhodium on alumina (0.26 g) in ethanol (10 mL) and concentrated NH4OH (5 mL) is placed under 55 psi hydrogen pressure on a Parr shaker. After 24 h at ambient temperature, the reaction mixture is filtered through Celite and concentrated in vacuo to afford the title amine, identified by NMR and mass spectral analyses.

Provenance & Evidence