HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → 4-(2,2,2-Trimethylacetamido)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2,2,2-Trimethylacetamido)pyridine | HCID 427059 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A solution of pivaloyl chloride (1.1 eq.) in CH2Cl2 is added to a solution of 4-aminopyridine (1 eq.) and triethylamine (1.2 eq.) in CH2Cl2, stirred at 0° C. for 2 h, washed with aqueous sodium bicarbonate, dried over MgSO4 and concentrated in vacuo. The resultant residue is purified by flash chromatography over silica gel to afford the title propionamide compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585876B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-95bc10cbfd334048859bbeb940f816fb |
| Source note | uspto-grants-2009_09 |