2-Amino-3-bromopyridine → 8-Bromo-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine

Participants

Reaction Steps

As described for Example 1, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using 2-amino-3-bromopyridine instead of 2-aminopyridine, to the title compound (85 mg, 48%) which was obtained as a yellow gum. MS: m/e=354.0/356.1 [M+H]+.

Provenance & Evidence