2-Amino-5-bromopyridine → HCID 24738993, compound

HRID 731635Notes

Reaction equation

HRID 731635 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][N:19]=1>>[Br:24][C:21]1[CH:22]=[CH:23][C:18]2[N:19]([CH:2]=[C:3]([C:5]3[C:6]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:7][O:8][C:9]=3[CH3:10])[N:17]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

Product 1

HCID 24738993HCID 24738993, compoundYield 42%

Procedure

As described for Example 1, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using 2-amino-5-bromopyridine instead of 2-aminopyridine, to the title compound (75 mg, 42%) which was obtained as a yellow gum. MS: m/e=354.1/356.0 [M+H]+.

Sources & evidence

ORD record
ord-9af54248dcb546f8abf11fd1a9a91a3a
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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