2-Amino-5-cyanopyridine → HCID 24739639, compound

HRID 731636Notes

Reaction equation

HRID 731636 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][N:19]=1>>[CH3:10][C:9]1[O:8][N:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]=1[C:3]1[N:17]=[C:18]2[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][N:19]2[CH:2]=1

Participants

3

Reactant 2

HCID 8182602-Amino-5-cyanopyridineHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

Product 1

HCID 24739639HCID 24739639, compoundYield 11%

Procedure

As described for Example 1, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using 2-amino-5-cyanopyridine instead of 2-aminopyridine, to the title compound (17 mg, 11%) which was obtained as a light yellow foam. MS: m/e=301.3 [M+H]+.

Sources & evidence

ORD record
ord-c760388d0b1341e7921f278a31030a7a
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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