Methyl 6-aminonicotinate → HCID 24738996, compound

HRID 731637Notes

Reaction equation

HRID 731637 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.[NH2:17][C:18]1[CH:27]=[CH:26][C:21]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][N:19]=1>>[CH3:25][O:24][C:22]([C:21]1[CH:26]=[CH:27][C:18]2[N:19]([CH:2]=[C:3]([C:5]3[C:6]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:7][O:8][C:9]=3[CH3:10])[N:17]=2)[CH:20]=1)=[O:23]

Participants

3

Reactant 2

HCID 737487Methyl 6-aminonicotinateHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

Product 1

HCID 24738996HCID 24738996, compoundYield 38%

Procedure

As described for Example 1, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using methyl 6-aminonicotinate instead of 2-aminopyridine, to the title compound (64 mg, 38%) which was obtained as a light yellow solid. MS: m/e=334.3 [M+H]+.

Sources & evidence

ORD record
ord-d499200678a74475ae5ebc8f6b17a497
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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