HCID 24738344, compound → HCID 69072661, compound

HRID 731638Notes

Reaction equation

HRID 731638 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[N:9]([CH:11]=[C:12]([C:14]3[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[N:16][O:17][C:18]=3[CH3:19])[N:13]=2)[CH:10]=1)=[O:4].COC(C1C=CN2C=C(C3C(C4C=CC=CC=4)=NOC=3C)N=C2C=1)=O>>[CH3:19][C:18]1[O:17][N:16]=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]=1[C:12]1[N:13]=[C:8]2[CH:7]=[CH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:10][N:9]2[CH:11]=1

Participants

3

Reactant 2

HCID 24738344HCID 24738344, compoundHCID 24738996HCID 24738996, compound

Product 1

HCID 69072661HCID 69072661, compoundYield 90%

Procedure

As described for Example 11a, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (2.0 g, 6.0 mmol), instead of 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester, was converted to the title compound (1.7 g, 90%) which was obtained as a yellow solid. MS: m/e=318.4 [M−H]−.

Sources & evidence

ORD record
ord-e7ab79e0ab014182959896d66d92701b
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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