HCID 69067892, compound → HCID 69064807, compound

HRID 731639Notes

Reaction equation

HRID 731639 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[CH:19][C:18]([C:21]([OH:23])=O)=[CH:17][N:16]2[CH:24]=1.CC1ON=C(C2C=CC=CC=2)C=1C1N=[C:39]2[CH:44]=[C:43](C(O)=O)[CH:42]=[CH:41][N:40]2C=1>>[CH:41]1([NH:40][C:21]([C:18]2[CH:19]=[CH:20][C:15]3[N:16]([CH:24]=[C:13]([C:3]4[C:4]([C:7]5[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=5)=[N:5][O:6][C:2]=4[CH3:1])[N:14]=3)[CH:17]=2)=[O:23])[CH2:42][CH2:43][CH2:44][CH2:39]1

Participants

3

Reactant 2

HCID 69067892HCID 69067892, compoundHCID 69072661HCID 69072661, compound

Product 1

HCID 69064807HCID 69064807, compoundYield 85%

Procedure

As described for Example 15, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-6-carboxylic acid (96 mg, 0.3 mmol), instead of 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-7-carboxylic acid, was converted to the title compound (98 mg, 85%) which was obtained as a light yellow foam. MS: m/e=387.3 [M+H]+.

Sources & evidence

ORD record
ord-af88662fc02e44c0ba3cddb89edf630f
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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