HCID 69067892, compound → HCID 16654996, compound

HRID 731640Notes

Reaction equation

HRID 731640 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[CH:19][C:18]([C:21](O)=[O:22])=[CH:17][N:16]2[CH:24]=1.C[C:26]1[O:30][N:29]=[C:28]([C:31]2[CH:36]=CC=CC=2)[C:27]=1C1N=C2C=C(C(O)=O)C=CN2C=1>>[O:30]1[CH2:26][CH2:27][CH:28]([NH:29][C:21]([C:18]2[CH:19]=[CH:20][C:15]3[N:16]([CH:24]=[C:13]([C:3]4[C:4]([C:7]5[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=5)=[N:5][O:6][C:2]=4[CH3:1])[N:14]=3)[CH:17]=2)=[O:22])[CH2:31][CH2:36]1

Participants

3

Reactant 2

HCID 69067892HCID 69067892, compoundHCID 69072661HCID 69072661, compound

Product 1

HCID 16654996HCID 16654996, compoundYield 76%

Procedure

As described for Example 17, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-6-carboxylic acid (64 mg, 0.2 mmol), instead of 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-7-carboxylic acid, was converted to the title compound (61 mg, 76%) which was obtained as an off white solid. MS: m/e=403.5 [M+H]+.

Sources & evidence

ORD record
ord-09975c24649c419da47bb658643b9149
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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