HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nicotinic Acid → N-[2-(5-Methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridin-7-yl]-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nicotinic Acid | HCID 938 | — |
| Reactant | 2-(5-Methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridin-7-ylamine | HCID 24738830 | — |
| Product | N-[2-(5-Methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridin-7-yl]-nicotinamide | HCID 24738834 | 14% |
Reaction Steps
As described for Example 48, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridin-7-ylamine (92 mg, 0.32 mmol) was converted, using nicotinic acid instead of cyclopropanecarboxylic acid, to the title compound (19.4 mg, 14%) which was obtained as an off-white solid. MS: m/e=396.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585874B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-b03bf1bbf72a498d9190484508eba366 |
| Source note | uspto-grants-2009_09 |