3-Pyridineacetic acid → HCID 24739476, compound

HRID 731653Notes

Reaction equation

HRID 731653 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][N:16]2[CH:22]=1.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][C:30](O)=[O:31])[CH:24]=1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:30](=[O:31])[CH2:29][C:25]3[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=3)=[CH:17][N:16]2[CH:22]=1

Participants

3

Reactant 2

HCID 1083-Pyridineacetic acidHCID 24739474HCID 24739474, compound

Product 1

HCID 24739476HCID 24739476, compoundYield 42%

Procedure

As described for Example 56, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridin-6-ylamine (96 mg, 0.33 mmol) was converted, using 3-pyridylacetic acid instead of cyclopropylacetic acid, to the title compound (26 mg, 42%) which was obtained as a light brown solid. MS: m/e=410.0 [M+H]+.

Sources & evidence

ORD record
ord-76838e46c6d24c79ad5ac0abd1f0c806
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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