Cyclopentanecarboxylic acid → HCID 24739638, compound

HRID 731656Notes

Reaction equation

[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][N:16]2[CH:22]=1.[CH:23]1([C:28](O)=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:28]([CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)=[O:29])=[CH:17][N:16]2[CH:22]=1

Participants

Reactant 2

HCID 18840Cyclopentanecarboxylic acid

HCID 24739474HCID 24739474, compound

Product 1

HCID 24739638HCID 24739638, compoundYield 48%

Procedure

As described for Example 56, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridin-6-ylamine (96 mg, 0.33 mmol) was converted, using cyclopentanecarboxylic acid instead of cyclopropylacetic acid, to the title compound (56 mg, 48%) which was obtained as an off-white solid. MS: m/e=387.3 [M+H]+.

Sources & evidence

ORD record: ord-b11bd41eecf146099e415b5c252e67cc
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07585874B2

Reaction notes

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