Nicotinic Acid → HCID 24739305, compound

HRID 731658Notes

Reaction equation

HRID 731658 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][N:16]2[CH:22]=1.[C:23](O)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[N:26][CH:25]=1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[N:26][CH:25]=3)=[CH:17][N:16]2[CH:22]=1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 24739474HCID 24739474, compound

Product 1

HCID 24739305HCID 24739305, compoundYield 80%

Procedure

As described for Example 56, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridin-6-ylamine (71 mg, 0.22 mmol) was converted, using nicotinic acid instead of cyclopropylacetic acid, to the title compound (63 mg, 80%) which was obtained as an off-white solid. MS: m/e=396.3 [M+H]+.

Sources & evidence

ORD record
ord-6c2adbb12a254082b0498f7994e79c32
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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