Imidazole → HCID 24739473, compound

HRID 731663Notes

Reaction equation

I[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[C:12]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[N:13][O:14][C:15]=3[CH3:16])[N:10]=2)[CH:7]=1.[NH:23]1[CH:27]=[CH:26][N:25]=[CH:24]1>>[N:23]1([C:2]2[CH:3]=[CH:4][C:5]3[N:6]([CH:8]=[C:9]([C:11]4[C:12]([C:17]5[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=5)=[N:13][O:14][C:15]=4[CH3:16])[N:10]=3)[CH:7]=2)[CH:27]=[CH:26][N:25]=[CH:24]1

Participants

Reactant 2

HCID 795Imidazole

HCID 24738994HCID 24738994, compound

Product 1

HCID 24739473HCID 24739473, compoundYield 29%

Procedure

As described for Example 60, 6-iodo-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine (47 mg, 0.13 mmol) was converted, using imidazole instead of benzamide, to the title compound (13 mg, 29%) which was obtained as a brown foam. MS: m/e=342.3 [M+H]+ as the most polar component.

Sources & evidence

ORD record: ord-196ae3a4a6a34711b88c676de5e14899
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07585874B2

Reaction notes

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