HCID 68545119, compound → HCID 57837520, compound

Participants

Reaction Steps

To a solution of 600 mg (4.6 mmol) of N-benzyl-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-amine in 10 ml of acetic acid was added 100 mg of PtO2 in hydrogenation bottle. H2 was applied at 50 psi for 4 hours. The reaction was worked up by filtration and dilution with 0.1N HCl to provide 503 mg of crude product. Purification by C18 preparative HPLC furnished 400 mg of purified 1-(2-isopropyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-amine after lyophilization. Compound 1011.

Provenance & Evidence