Sodium Iodide → HCID 68550400, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 980 mg (3.90 mmol) of 2-chloro-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one, 1.45 g (4 mmol) of N-Boc-piperazine and 100 mg of NaI in 10 ml of MeOH was stirred at 50-70° C. for 5 hours. The residue obtained after evaporation of the solvent was purified on an Al2O3 column. The fractions containing purified product were titrated with 4N HCl-dioxane to obtain a precipitate. Recrystallization from isopropanol/ether produced 150 mg of 1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-(piperazin-1-yl)propan-1-one hydrochloride. Compound 1037.

Provenance & Evidence