HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyryl chloride → 1-(2-Methoxypyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 2-Methoxypyrazolo[1,5-a]pyridine | HCID 12284427 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 1-(2-Methoxypyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one | HCID 57837523 | 31.5% |
Reaction Steps
A mixture of 700 mg (4.7 mmol) of 2-methoxypyrazolo[1,5-a]pyridine, 550 mg of isobutyryl chloride and 300 mg of AlCl3 was stirred in 2 ml of DCE at RT for 5 hours. The reaction was quenched with saturated NH4Cl and extracted with ethyl acetate to yield 1 g of crude product. Purification on an Al2O3 column furnished 323 mg of 1-(2-methoxypyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one. Compound 1055.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585875B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-3d8528f042ba4eb88cf8545a86b21577 |
| Source note | uspto-grants-2009_09 |