HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 23658968, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | HCID 86637278 | HCID 86637278 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 23658968 | HCID 23658968 | 61.4% |
Reaction Steps
A mixture of 200 mg (0.63 mmol) of 2-chloro-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)ethanone, 100 mg of thiourea and 160 mg of sodium hydride were stirred in 2 ml of dioxane containing 120 μl of H2O at 60-70° C. for 30 minutes. 100 mg of 4-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)thiazol-2(5H)-imine was obtained after workup. Compound 1087.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585875B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-9bda2ad693944810ac5894060a777556 |
| Source note | uspto-grants-2009_09 |