HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 57837498, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | 2-Chloro-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone | HCID 21585751 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57837498 | HCID 57837498 | 86.8% |
Reaction Steps
A solution of 2-chloro-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one (1.0 g, 1 equivalent) and potassium acetate (0.6 g, 1.5 equivalents) in 5 mL of DMF was stirred at room temperature for 2 days. The solution was worked up with ethyl acetate and water to give a crude oil. The oil was purified by silica gel flash column chromatography to furnish 1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-1-oxopropan-2-yl acetate (0.95 g, 86% yield) as a paste. Compound 1067.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585875B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-1601d389774b440d9afe3355442711e8 |
| Source note | uspto-grants-2009_09 |