(4-(Morpholin-4-yl)phenyl)boronic acid → HCID 57837448, compound

Participants

Reaction Steps

2-Isopropyl-3-(4-morpholin-4-yl-phenyl)-pyrazolo[1,5-a]pyridine was prepared from 3-iodo-2-isopropyl-pyrazolo[1,5-a]pyridine and 4-morpholinophenylboronic acid following the method used in Step 3 of the synthesis of 3-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3-yl)-phenylamine (Example 59) (157 mg, 16%). 1H-NMR (250 MHz, DMSO-d6) δ 8.61 (d, J=6.3 Hz, 1H), 7.45 (d, J=9.0 Hz, 1H), 7.30 (d, J=7.0 Hz, 2H), 7.15-7.06 (m, 3H), 6.81 (t, J=6.5 Hz, 1H), 3.79-3.75 (m, 4H), 3.25 (sept, J=6.3 Hz, 1H), 3.22-3.15 (m, 4H), 1.27 (d, J=6.8 Hz, 6H); LC/MS 322.3 m/z (M+H+). Compound 1102.

Provenance & Evidence