2-Methyl-2-thiopseudourea sulfate → HCID 178480876, compound

HRID 731747Notes

Reaction equation

HRID 731747 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][NH2:11])[CH2:4][CH2:3]1.S(O)(O)(=O)=O.CS[C:19](=[NH:21])[NH2:20].C(NC1N=C(C2C(C(C)C)=NN3C=CC=CC=23)C=CN=1)(C)C>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:19]([NH2:21])=[NH:20])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 752702-Methyl-2-thiopseudourea sulfateHCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 49841325HCID 49841325, compound

Product 1

HCID 178480876HCID 178480876, compound

Procedure

N-[3-(4-Methyl-piperazin-1-yl)-propyl]-guanidine was prepared from 3-(4-methyl-piperazin-1-yl)-propylamine and 2-methyl-2-thiopseudourea sulfate following the method used in Step 3 of the synthesis of Isopropyl-[4-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl]-amine (Example 66). LC/MS 200.2 m/z (M+H+).

Sources & evidence

ORD record
ord-81bbf938edb642ce9d6887796f1c1a43
Source dataset
uspto-grants-2009_09
Patent number
US07585875B2

Reaction notes

Loading…