Water → 1-ethyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Iodoethane	HCID 6340	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	HCID 178508705	HCID 178508705	—
Solvent	Dimethylformamide	HCID 6228	—
Product	1-ethyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	HCID 24905270	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (100 mg, 0.42 mmol) was dissolved in DMF (3 mL) and K2CO3 (220 mg, 1.6 mmol) and ethyl iodide (37 μL, 0.46 mmol) were added. The reaction was heated to 60° C. overnight, then cooled to RT and poured into water (30 mL). The precipitate was collected by filtration. ESI-MS (M+H)+ m/z calcd 290.1, found 290.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07585868B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-beb4e77a062f482d85eda3dc514da12f
Source note	uspto-grants-2009_09