HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 731887Generated: October 27, 2026
Water → 1-cyclopentyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
https://huagongshe.com/reaction/731887
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Bromocyclopentane | HCID 8728 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 178508705 | HCID 178508705 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-cyclopentyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | HCID 24866805 | — |
Reaction Steps
3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (100 mg, 0.42 mmol) was dissolved in DMF (3 mL) and K2CO3 (220 mg, 1.6 mmol) and cyclopentyl bromide (49.5 μL, 0.46 mmol) were added. The reaction was heated to 60° C. overnight, then cooled to RT and poured into water (30 mL). The precipitate was collected by filtration. ESI-MS (M+H)+ m/z calcd 330.2, found 330.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07585868B2 |
|---|
| Source dataset | uspto-grants-2009_09 |
|---|
| ORD ID | ord-52987593af64416a95039cb580cb8fce |
|---|
| Source note | uspto-grants-2009_09 |
|---|
