HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 731891Generated: October 27, 2026
Water → 1-(3-Methylbutyl)-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
https://huagongshe.com/reaction/731891
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Bromo-2-methylpropane | HCID 6555 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 178508705 | HCID 178508705 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-Methylbutyl)-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine | HCID 52943258 | — |
Reaction Steps
3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (50 mg, 0.21 mmol) was dissolved in DMF (1.5 mL) and K2CO3 (110 mg, 0.8 mmol) and isobutyl bromide were added. The reaction was heated to 60° C. overnight, then cooled to RT and poured into water (30 mL). The precipitate was collected by filtration. ESI-MS (M+H)+ m/z calcd 332.2, found 332.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07585868B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-e37b1322a9e44f8785dc174f252f687c |
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| Source note | uspto-grants-2009_09 |
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