Trifluoroacetic acid → N-[(3s)-1-{(2s)-1-[(3s)-3-Aminopiperidin-1-Yl]-1-Oxopropan-2-Yl}-2-Oxopyrrolidin-3-Yl]-6-Chloronaphthalene-2-Sulfonamide

Participants

Reaction Steps

Benzyl (3S)-1-[(2S)-2-((3S)-3-{[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoyl]piperidin-3-ylcarbamate (0.128 g) was dissolved in DCM (3.5 ml) and treated with trifluoroacetic acid (10.5 ml) and stirred at room temperature for 6 h. The mixture was concentrated under reduced pressure and the residue purified by SPE (acid ion-exchange, eluting with ethyl acetate:methanol 9:1) to give the title compound (0.093 g) as a colourless oil.

Provenance & Evidence