Cyclopentylacetyl chloride → 2-Cyclopentyl-1-{4-[4-(6-fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-piperidin-1-yl}-ethanone

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared from (6-Fluoro-pyrido[3,4-d]pyrimidin-4-yl)-[3-methyl-4-(piperidin-4-yloxy)-phenyl]-amine (T) and cyclopentylacetyl chloride by a procedure analogous to that described for the synthesis of Cyclopentyl-{4-[4-(6-fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-piperidin-1-yl}-methanone. MS: 464.3 (MH+); 1H NMR (DMSO-d6, 400 MHz): δ 9.90 (s, 1H), δ 8.86 (s, 1H), δ 8.57 (s, 1H), δ 8.19 (s, 1H), δ 7.035 (d, J=9.97, 2H), δ 4.58-4.59 (m, 1H), δ 3.71 (m, 2H), δ 3.30-3.93 (m, 2H), δ 2.31 (d, J=7.47, 2H), δ 2.17 (s, 3H), δ 2.08-2.12 (m, 1H), δ 1.80-1.95 (m, 1H), δ 1.43-1.73 (m, 10H), δ 1.05-1.10 (m, 2H).

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