m-Anisoyl chloride → (3-Methoxy-phenyl)-{4-[2-methyl-4-(6-morpholin-4-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-piperidin-1-yl}-methanone

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Reaction Steps

The title compound was prepared from [3-Methyl-4-(piperidin-4-yloxy)-phenyl]-(6-morpholin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)-amine and 3-methoxy benzoylchloride by a procedure analogous to the synthesis of Cyclopentyl-{4-[4-(6-fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-piperidin-1-yl}-methanone. LRMS: 555.2 (MH+). 1H NMR (DMSO-d6, 400 MHz): δ 9.57 (s, 1H), δ 8.79 (s, 1H), δ 8.32 (s, 1H), δ 7.47-7.53 (m, 3H), δ 7.32 (t, J=7.68, 1H), δ 7.31 (d, J=8.72, 1H), δ 6.93-6.99 (m, 3H), δ 4.62 (br. s, 1H), δ 3.76 (br. s, 1H), δ 3.52-3.54 (m, 6H), δ 3.75 (m, 6H), 3.302 (s, 3H), δ 2.18 (s, 3H), δ 1.97 (br. s, 1H), δ 1.90 (br. s, 1H), δ 1.66 (br. s, 1H).

Provenance & Evidence