Pyrrolidine → HCID 11340957, compound

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Reaction Steps

The Title compound was prepared from 3-[4-(6-Fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-benzoic acid tert-butyl ester and pyrrolidine by a procedure analogous to that described for the synthesis of Cyclopentyl-{4-[2-methyl-4-(6-pyrrolidin-1-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-piperidin-1-yl}-methanone. LRMS: 498.3 (MH+). 1H NMR (DMSO-d6, 400 MHz): δ 9.60 (s, 1H), δ 8.76 (s, 1H), δ 8.31 (s, 1H), δ 7.73-7.76 (m, 2H), δ 7.56-7.58 (m, 1H), δ 7.45 (t, J=7.89, 1H), δ 7.31-7.32 (m, 1H), δ 7.13-7.16 (m, 1H), δ 7.09 (s, 1H), 7.01 (d, J=9.14, 1H), δ 3.45-3.48 (m, 4H), δ 2.15 (s, 3H), δ 1.97-2.01 (m, 4H), δ 1.48 (s, 9H).

Provenance & Evidence