HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-[2-Methyl-4-(6-pyrrolidin-1-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 11340957 | HCID 11340957 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[2-Methyl-4-(6-pyrrolidin-1-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-benzoic acid | HCID 69051988 | 100% |
Reaction Steps
Trifluoro acetic acid (10 mL) was added to a solution of 3-[2-Methyl-4-(6-pyrrolidin-1-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-benzoic acid tert-butyl ester (0.40 g, 0.82 mmol) in CH2Cl2 (10 mL). After 12 h the reaction was concentrated to give a red solid (0.36 g, 100%). LRMS: 4.42 (MH+), HPLC Rf: 8.34 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585869B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-4aa743b178dc470192468c69da56126c |
| Source note | uspto-grants-2009_09 |