Tert-butyl 4-(4-amino-2-methylphenoxy)benzoate → 4-[4-(6-Fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-benzoic acid tert-butyl ester

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Reaction Steps

The title compound was prepared from 6-Fluoro-3H-pyrido[3,4-d]pyrimidin-4-one and 4-(4-Amino-2-methyl-phenoxy)-benzoic acid tert-butyl ester by a procedure analogous to the synthesis of 3-[4-(6-Fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-benzoic acid tert-butyl ester above. LRMS: 447.3/391.2 (MH+); 1H NMR (DMSO-d6, 400 MHz): δ 10.03 (s, 1H), δ 8.90 (s, 1H), δ 8.65 (s, 1H), δ 8.24 (s, 1H), δ 7.75-7.87 (m, 4H), δ 7.07 (d, J=8.73, 1H), δ 6.90-6.93 (m, 2H), δ 2.12 (s, 3H), δ 1.49 (s, 9H).

Provenance & Evidence