Morpholine → 4-[2-Methyl-4-(6-morpholin-4-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-benzoic acid tert-butyl ester

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The title compound was prepared from 4-[4-(6-Fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-benzoic acid tert-butyl ester and morpholine by a procedure analogous to the synthesis of [3-Methyl-4-(piperidin-4-yloxy)-phenyl]-(6-morpholin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)-amine. LRMS: 498.4 (MH+). 1H NMR (DMSO-d6, 400 MHz): δ 9.74 (s, 1H), δ 8.87 (s, 1H), δ 8.45 (s, 1H), δ 7.89-7.92 (m, 2H), δ 7.80-δ 7.83 (m, 2H), δ 7.55 (s, 1H), δ 7.12 (d, J=9.64, 1H), δ 6.95-6.98 (m, 2H), δ 3.80-3.83 (m, 4H), δ 3.58-δ 3.61 (m, 4H), δ 2.17 (s, 3H), δ 1.54 (s, 9H).

Provenance & Evidence