HRID731920

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cc(Nc2ncnc3cnc(N4CCOCC4)cc23)ccc1Oc1ccc(C(=O)OC(C)(C)C)cc1

HCID69052998

未命名化合物

结构：Cc1cc(Oc2c(Nc3ncnc4cnccc34)cccc2N2CCCC2)ccc1C(=O)O

HCID86595239

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(Nc2ncnc3cnc(N4CCOCC4)cc23)ccc1Oc1ccc(C(=O)O)cc1

HCID69050737

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4-[2-Methyl-4-(6-morpholin-4-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-benzoic acid tert-butyl ester by a procedure analogous to the synthesis of 3-[2-Methyl-4-(6-pyrrolidin-1-yl-pyrido[3,4-d]pyrimidin-4-ylamino phenoxy]-benzoic acid. LRMS: 458.3 (MH+) HPLC Rf: 5.94 min.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9d112eab10b43f098499dda867d7e79
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07585869B2
来源说明: uspto-grants-2009_09

反应 SMILES

C([O:5][C:6](=[O:38])[C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21]3[C:22]4[CH:30]=[C:29]([N:31]5[CH2:36][CH2:35][O:34][CH2:33][CH2:32]5)[N:28]=[CH:27][C:23]=4[N:24]=[CH:25][N:26]=3)=[CH:16][C:15]=2[CH3:37])=[CH:9][CH:8]=1)(C)(C)C.CC1C=C(OC2C(N3CCCC3)=CC=CC=2NC2C3C=CN=CC=3N=CN=2)C=CC=1C(O)=O>>[CH3:37][C:15]1[CH:16]=[C:17]([NH:20][C:21]2[C:22]3[CH:30]=[C:29]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)[N:28]=[CH:27][C:23]=3[N:24]=[CH:25][N:26]=2)[CH:18]=[CH:19][C:14]=1[O:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]([OH:38])=[O:5])=[CH:8][CH:9]=1