Tert-Butylamine → N-tert-Butyl-4-[2-methyl-4-(6-morpholin-4-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-benzamide

Participants

Reaction Steps

The title compound was prepared from 4-[2-Methyl-4-(6-morpholin-4-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-benzoic acid and tert-butyl amine by a procedure analogous to the synthesis of N-tert-Butyl-3-[2-methyl-4-(6-pyrrolidin-1-yl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenoxy]-benzamide. LRMS: 513.4 (MH+); 1H NMR (DMSO-d6, 400 MHz): δ 9.77 (s, 1H), δ 8.83 (s, 1H), δ 8.42 (s, 1H), δ 7.72-7.78 (m, 4H), δ 7.63 (s, 1H), δ 7.51 (s, 1H), δ 7.03 (d, J=9.14, 1H), δ 6.87 (d, J=8.72, 2H), δ 3.75-3.77 (m, 4H), δ 3.54-3.56 (m, 4H), δ 2.14 (s, 3H), δ 1.33 (s, 9H).

Provenance & Evidence