Ethanol hydrochloride → 7-Aminoquinolin-2(1H)-one

HRID 731950Notes

Reaction equation

HRID 731950 reaction equation
Cl.C(O)C.[O:5]=[C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][C:10]([NH:16]C(=O)C)=[CH:11][CH:12]=2)[NH:7]1>>[NH2:16][C:10]1[CH:9]=[C:8]2[C:13]([CH:14]=[CH:15][C:6](=[O:5])[NH:7]2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 23112256HCID 23112256, compound

Product 1

HCID 189415427-Aminoquinolin-2(1H)-one

Procedure

A 1.2M hydrochloric acid-ethanol solution of N-(2-oxo-1,2-dihydroquinolin-7-yl)acetamide was heated under reflux to obtain 7-aminoquinolin-2(1H)-one.

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-6ae614e7b88f440cbcb5981ac1a9c522
Source dataset
uspto-grants-2009_09
Patent number
US07585878B2

Reaction notes

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